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November 3, 2021 2:00 pm / 3:00 pm

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Urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) are widely used in epidemiology studies as exposure biomarkers of air pollution. However, because PAHs are originated from petrogenic (e.g., oil drilling) and generic combustion sources, it is difficult to attribute PAHs-associated health effects to a specific pollution source. Certain PAH derivatives are more source-specific than PAHs. Hence, biomonitoring their metabolites may present a method to assess exposures to specific sources. In this talk, Dr. Lin will summarize findings from human studies linking urinary alkylated- and nitrated-PAHs metabolites to petrogenic processes and diesel exhaust, respectively. He will also present evidence from real-world studies in multiple urban locations associating these urinary biomarkers to human’s pathophysiologic changes.

Photo of Yan Lin

Yan Lin is a postdoctoral associate in Jim Zhang’s laboratory at Duke Global Health Institute. He received his Ph.D. from UCLA EHS department in 2019 under the supervision of Yifang Zhu. Yan’s research primarily aims to illustrate the impact of air pollution on population’s exposure to toxic chemicals (e.g., polycyclic aromatic hydrocarbons) and the subsequent health effects, which has resulted in more than 30 peer-reviewed publications in environmental and medical journals. His current research focused on (1). developing novel exposure biomarkers with increased specificity to pollution sources; and (2). examining biological mechanisms linking air pollution to cardiopulmonary diseases and adverse birth outcomes.

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